Sistina
The Upper East Side's Italian wine fortress
Upper East Side Β· New York Β· Italian Β· Visit Website β
Reviewed April 5, 2026
Wingman Metrics
First Impression
Walk into Sistina and the wine list arrives like a small novel β somewhere between 1,200 and 1,800 bottles deep, organized with the kind of seriousness that tells you immediately this place takes wine as seriously as it takes its decades-long Upper East Side reputation. This is old-school Italian dining done with conviction, and the cellar backs it up. Wine Spectator has handed out Grand Awards here since 2018, and one look at the list tells you exactly why.
Selection Deep Dive
The Italian section is the obvious centerpiece: Tuscany and Piedmont are covered at a depth that most dedicated wine bars can't touch. Sassicaia, Ornellaia, Masseto, Solaia, and Tignanello anchor the Super Tuscan column, while the Barolo lineup reads like a Piedmont hall of fame β Giacomo Conterno, Bruno Giacosa, and Gaja all present and accounted for. Biondi-Santi and Casanova di Neri (Giacomo Neri) hold down Brunello di Montalcino with appropriate gravitas. France isn't an afterthought either: Bordeaux royalty like ChΓ’teau PΓ©trus and ChΓ’teau Lafite Rothschild share shelf space with Domaine de la RomanΓ©e-Conti, and California's prestige tier β Opus One, Screaming Eagle β rounds out a list built for serious collectors and serious celebrators alike.
By the Glass
With 20 to 30 options by the glass, Sistina offers more pour flexibility than most white-tablecloth Italian spots in the city. The selection skews Italian and classic, which is exactly what you want here. We'd steer toward whatever Nebbiolo or Sangiovese is open on a given night β the staff know what they're pouring and can point you in the right direction.
Tignanello (Antinori) β $180
In a list where bottles routinely push into the thousands, Tignanello is the entry point into serious Super Tuscan territory β a benchmark wine that consistently punches above its price relative to its neighbors on this list. Not cheap, but it's the move if you want to drink something iconic without ordering a mortgage payment.
Brunello di Montalcino, Casanova di Neri (Giacomo Neri)
In the shadow of Biondi-Santi β which gets all the headlines and commands the bigger price tags β Casanova di Neri quietly delivers some of the most compelling Brunello on the market. Most diners order past it chasing bigger names. Don't.
Screaming Eagle
Yes, it's on the list. Yes, it's Screaming Eagle. And yes, the markup at a restaurant like this will be punishing in a way that makes even fans of the wine wince. This is a trophy pour for people expensing dinner, not a smart way to spend your wine budget here.
Barolo, Bruno Giacosa + Eggplant Parmigiana
Giacosa's Barolo brings the kind of grippy tannin and dried rose depth that cuts right through the richness of a properly made Eggplant Parmigiana β the tomato acidity in the dish softens the wine, and the wine makes the dish taste more like itself. Classic match, no tricks required.
π₯ The Bottom Line
Sistina is the real deal β a 40-year-old Upper East Side institution with a cellar that earns its Grand Award year after year. Markups are what they are at this level, but if you're going to spend serious money on Italian wine anywhere in New York, this is one of the rooms worth doing it in.
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